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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T14342 | Atorvastatin lactone | HMG-CoA Reductase | |
Atorvastatin lactone is a prodrug form of atorvastatin. Which is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. | |||
T20765 | Atorvastatin | HMG-CoA Reductase , Autophagy | |
Atorvastatin is an orally active HMG-CoA reductase inhibitor that has the ability to effectively lower blood lipids by activating liver cytochrome p450 to accelerate metabolism. Atorvastatin inhibited proliferation and i... | |||
T79520 | HMG-CoA Reductase-IN-1 | ||
HMG-CoA Reductase-IN-1 is an inhibitor of HMG-CoA reductase, demonstrating strong inhibitory activity on HMGR and affinity for OATP1B1, with pIC50 and pKm values of 8.54 and 1.98, respectively. It is utilized in hypercho... | |||
TN1733 | Hesperetin 7-O-glucoside | Anti-infection , Antibacterial , HMG-CoA Reductase | |
Hesperetin 7-O-glucoside and prunin are direct precursors of naringin and neohesperidin, respectively, in C. aurantium. Hesperetin 7-O-glucoside shows inhibition of human HMG-CoA reductase, it also exhibits effective inh... | |||
TN6715 | 7-Ketocholesterol | Others | |
7-Ketocholesterol is a metabolite of Cholesterol | |||
TN1438 | Beta-Amyrin acetate | Antioxidant , HMG-CoA Reductase , Epoxide Hydrolase , Antifungal | |
beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, and anti-hyperlipidemic activities. | |||
T1207 | Lovastatin | MK-803,Mevinolin | Ferroptosis , HMG-CoA Reductase , Autophagy |
Lovastatin (MK-803) is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol. | |||
T1487 | Fluvastatin sodium | XU 62320 sodium,XU-62-320,Fluvastatin sodium salt | Ferroptosis , HMG-CoA Reductase , Autophagy |
Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent. | |||
T6450 | Clinofibrate | S-8527,Lipoclin | HMG-CoA Reductase , Autophagy |
Clinofibrate (Lipoclin)(IC50 of 0.47 mM), a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholesterol and triacylglyceride levels in the blood. | |||
T0683 | Mevastatin | Compactin,ML236B | Apoptosis , Antibacterial , Antibiotic , HMG-CoA Reductase , Autophagy , Lipid |
Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials. | |||
T6994 | SR12813 | SR-12813,SR 12813,GW 485801 | HMG-CoA Reductase , Autophagy |
SR12813 (GW 485801) is a pregnane X receptor (PXR) agonist. | |||
T1664 | Meglutol | Dicrotalic acid,3-Hydroxy-3-methylglutaric acid | Endogenous Metabolite , HMG-CoA Reductase , Autophagy |
Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conve... | |||
T12092 | Monacolin J | Antibiotic MB 530A,Lovastatin diol lactone | HMG-CoA Reductase , Autophagy |
Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor. | |||
T0672 | Pravastatin sodium | CS-514 Sodium,CS-514 (sodium) | Ferroptosis , HMG-CoA Reductase , Autophagy |
Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM. | |||
T1676 | Rosuvastatin | ZD 4522 | Potassium Channel , HMG-CoA Reductase , Autophagy |
Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting... | |||
T3116 | Atorvastatin hemicalcium salt | Lipitor,Atorvastatin hemicalcium,Atorvastatin Calcium,CI-981,Sortis | Ferroptosis , HMG-CoA Reductase , Autophagy |
Atorvastatin hemicalcium salt (Atorvastatin Calcium), an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication. | |||
T0687 | Simvastatin | MK-0733,MK 733 | Apoptosis , Mitophagy , Ferroptosis , HMG-CoA Reductase , Autophagy |
Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovasc... | |||
T2534 | Pitavastatin calcium | P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,NK-104 | Apoptosis , Mitophagy , Endogenous Metabolite , HMG-CoA Reductase , Autophagy |
Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cyt... | |||
T1510 | Rosuvastatin calcium | ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium | Potassium Channel , HMG-CoA Reductase , Autophagy |
Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity. | |||
T21405 | Fluvastatin | Canef,XU-62320,Vastin,Cranoc,Lescol | HMG-CoA Reductase |
Fluvastatin (XU-62320) is a potent and competitive HMG-CoA reductase inhibitor (IC50: 8 nM) that inhibits oxidative stress in vascular smooth muscle cells through an Nrf2-dependent pathway, and is used for the reduction ... |